Surv BioPharma Inc.
![](https://www.survbiopharma.co.jp/wp-content/uploads/2023/12/logo.png)
Technology Platform
Our Core Strengths: A technology platform that enables viral replication control
- Our founder Professor Kosai developed a proprietary technology platform for constructing m-CRAs with various tissue- and tumor-specific replication properties. He first removed the endogenous promoter required for viral replication from the human adenovirus backbone and then inserted tissue- and-tumor-specific promoters at its appropriate positions.
- Despite attempts in the 1990s to develop treatments using non-replicating (“replication-defective”) adenoviral vectors, the resulting therapeutic viruses did not elicit adequate response due to their limited ability of propagation. Replication-regulated adenoviral vectors subsequently emerged but only a single factor was used to support/regulate its replication, resulting in inadequate cancer cell specificity.
- Using our proprietary technology, Surv BioPharma has succeeded in enhancing cancer cell specificity by precisely regulating viral replication with multiple cancer-specific factors. In addition, it is developing viruses carrying genes with therapeutic effects on cancers as well as genes for curing certain other diseases.
![](https://www.survbiopharma.co.jp/wp-content/uploads/2023/12/plat1-1.jpg)
Our Core Strengths: A technology platform that enables viral optimization
![](https://www.survbiopharma.co.jp/wp-content/uploads/2024/01/plat2_en-1024x486.jpg)